2009;21(7):762-770. Metab Brain Dis 2011;26(4):281-289. View abstract. Levocarnitine administration in multiple sclerosis patients with immunosuppressive therapy-induced fatigue. Tejani, A. M., Wasdell, M., Spiwak, R., Rowell, G., and Nathwani, S. Carnitine for fatigue in multiple sclerosis. Along with its needed effects, levocarnitine (the active ingredient contained in L-Carnitine) may cause some unwanted effects. We comply with the HONcode standard for trustworthy health information. View abstract. Am J Clin Nutr 1980;33(7):1489-1492. View abstract. [Ref], Very common (10% or more): Hypercalcemia (15%), hypervolemia (12%), Common (1% to 10%): Anorexia, hyperkalemia[Ref], Very common (10% or more): Pain (35%), flu syndrome (29%), chest pain (15%), accidental injury (12%), asthenia (12%), fever (12%), Common (1% to 10%): Peripheral edema, weight decrease, weight increase, Very rare (less than 0.01%): Body odor, International Normalized Ratio (INR) increased[Ref], Very common (10% or more): Injection site reaction (38%)[Ref], Musculoskeletal side effects, in chronic hemodialysis patients, for levocarnitine (the active ingredient contained in L-Carnitine) in relation to placebo therapy have included asthenia (8% to 12% vs 8%) and leg cramps (4% to 8% vs 13%). 2008;47(11):934-937. Gheissari A, Aslani N, Eshraghi A, et al. Effect of Levocarnitine on the Therapeutic Efficacy of Conventional Therapy in Children with Dilated Cardiomyopathy: Results of a Randomized Trial in 29 Children. Benton, D. and Donohoe, R. T. The influence on cognition of the interactions between lecithin, carnitine and carbohydrate. G.Ital.Cardiol. 2007;22(6):330-337. BMC Cardiovasc Disord. 1997;37(3 Pt 1):491-493. Fagher, B., Cederblad, G., Eriksson, M., Monti, M., Moritz, U., Nilsson-Ehle, P., and Thysell, H. L-carnitine and haemodialysis: double blind study on muscle function and metabolism and peripheral nerve function. On carnitine content of the human breast milk. View abstract. Hurot JM, Cucherat M, Haugh M, Fouque D. Effects of L-carnitine supplementation in maintenance hemodialysis patients: a systematic review. View abstract. List of All Orphan Products Designations and Approvals. Wang, S. B., Weng, W. C., Lee, N. C., Hwu, W. L., Fan, P. C., and Lee, W. T. Mutation of mitochondrial DNA G13513A presenting with Leigh syndrome, Wolff-Parkinson-White syndrome and cardiomyopathy. 2013 Jul;27 Suppl 2:6-11. Arch.Pediatr 2012;19(2):184-193. Le Tourneau, C., Faivre, S., Ciruelos, E., Dominguez, M. J., Lopez-Martin, J. Guarnieri, G. F., Ranieri, F., Toigo, G., Vasile, A., Ciman, M., Rizzoli, V., Moracchiello, M., and Campanacci, L. Lipid-lowering effect of carnitine in chronically uremic patients treated with maintenance hemodialysis. 2009;79(3):131-141. View abstract. If you happen to feel nausea, next time just take this supplement with food or take a lesser dose. I. Carnitine concentrations and lipid effects." Int J Clin Pharmacol Res 1990;10:75-9. El Beshlawy, A., Mohtar, G., Abd El, Ghafar E., Abd El Dayem, S. M., El Sayed, M. H., Aly, A. 2010;7:16. View abstract. J Am.Board Fam.Med. Stuessi, C., Hofer, P., Meier, C., and Boutellier, U. L -Carnitine and the recovery from exhaustive endurance exercise: a randomised, double-blind, placebo-controlled trial. 2010;5(8):e12140. J Clin Endocrinol Metab. Decombaz, J., Deriaz, O., Acheson, K., Gmuender, B., and Jequier, E. Effect of L-carnitine on submaximal exercise metabolism after depletion of muscle glycogen. Onofrj M, Fulgente T, Melchionda D, et al. Seems to help my energy and especially notice that my gums seem healthier while taking it. Leuk Lymphoma. 2005;59(4):592-596. A., Gupta, A., Vajifdar, B. U., and Lokhandwala, Y. Y. L-carnitine moderately improves the exercise tolerance in chronic stable angina. Curr Ther Res 1980;27(2):208-216. View abstract. Carnitor (levocarnitine)." Rev.Salud Publica (Bogota.) Holme E, Greter J, Jacobson CE, et al. Rebouche CJ. Does L carnitine coffee make you lose weight? View abstract. You may report side effects to FDA at 1-800-FDA-1088. Lisinopril (lisinipril) can cause nausea, headaches, anxiety, insomnia, drowsiness, nasal congestion and sexual dysfunction. (20,39) Since L-carnitine has a central role in fat metabolism and has significant antioxidant properties as well, carnitine supplementation has been investigated as a treatment option in the management of type 2 diabetes. View abstract. Carnitine produces energy in the cells by transporting fatty acids into the mitochondria where they are oxidized into . Curr Drug Targets. Am.J Kidney Dis 2007;50(5):803-812. Milazzo, L., Menzaghi, B., Caramma, I., Nasi, M., Sangaletti, O., Cesari, M., Zanone, Poma B., Cossarizza, A., Antinori, S., and Galli, M. Effect of antioxidants on mitochondrial function in HIV-1-related lipoatrophy: a pilot study. View abstract. 1993;25(6):733-740. Tsoko M, Beauseigneur F, Gresti J, et al. 2011;17(7):H55-H59. Ismail AM, Hamed AH, Saso S, Thabet HH. It can cause nausea, abdominal cramps, vomiting, and diarrhea when taken in high doses. View abstract. The process is the ability to heal the body, which is a daily process. Iran J Kidney Dis 2011;5(2):114-118. Am.J Emerg.Med. View abstract. View abstract. 2012;4:CD006282. 12-7-2005;11(45):7197-7202. Li, B., Lloyd, M. L., Gudjonsson, H., Shug, A. L., and Olsen, W. A. 2010;38:152-5. Cai, T., Wagenlehner, F. M., Mazzoli, S., Meacci, F., Mondaini, N., Nesi, G., Tiscione, D., Malossini, G., and Bartoletti, R. Semen quality in patients with Chlamydia trachomatis genital infection treated concurrently with prulifloxacin and a phytotherapeutic agent. The evidence is mixed when it comes to L-carnitines effects on sports performance. 2010;62(3):213-218. Am.J Cardiol. (1) On top of the limitations in positive studies, it has also shown to be completely useless. Taking L-carnitine with thyroid hormone might decrease the effectiveness of the thyroid hormone. 2010;30(4):233-239. Thal LJ, Carta A, Clarke WR, et al. Nephron Clin.Pract. View abstract. A single-center prospective pilot study. Colombani P, Wenk C, Kunz I, et al. Prolonged moderate-intensity exercise without and with L-carnitine supplementation in patients with MCAD deficiency. View abstract. View abstract. (Pakistan) 2006;6(5):800-805. It also caused me to urinate a lot. Scand.J Gastroenterol. View abstract. Eur.Urol. Zhonghua Er.Ke.Za Zhi. A., Pollard, P., Dumez, H., del Muro, X. G., and Paz-Ares, L. Phase II randomized study of Plitidepsin (Aplidin), alone or in association with L-carnitine, in patients with unresectable advanced renal cell carcinoma. J Autism Dev.Disord. Cuturic, M., Abramson, R. K., Moran, R. R., and Hardin, J. W. Clinical outcomes and low-dose levocarnitine supplementation in psychiatric inpatients with documented hypocarnitinemia: a retrospective chart review. View abstract. View abstract. Physiologie. In specific cases, this form may even protect your brain from cell damage. Brevetti G, Chiariello M, Policicchio A, and et al. This medicine works best if you take it with a meal or within 30 minutes after a meal. View abstract. The role of oral L-carnitine therapy in chronic hemodialysis patients. [Effect of L-carnitine on post-stress metabolism in surgical patients]. Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses. 2020;151:104554. A., Borum, P., Stall, C., Millspaugh, J., Taggart, E., and Lum, G. Carnitine status of pediatric patients on continuous ambulatory peritoneal dialysis. Ramos AC, Elias PR, Barrucand L, Da Silva JA. Circulation 1988;77:767-73. Antioxidant treatment with carnitines is effective in infertile patients with prostatovesiculoepididymitis and elevated seminal leukocyte concentrations after treatment with nonsteroidal anti-inflammatory compounds. First, take your CoQ10 with a meal. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's Disease. Propionyl-L-carnitine in intermittent claudication: double-blind, placebo-controlled, dose titration, multicenter study. View abstract. Effects of exercise intensity and altered substrate availability on cardiovascular and metabolic responses to exercise after oral carnitine supplementation in athletes. Kahn J, Lagakos S, Wulfsohn M, et al. Mantovani, G., Maccio, A., Madeddu, C., Gramignano, G., Serpe, R., Massa, E., Dessi, M., Tanca, F. M., Sanna, E., Deiana, L., Panzone, F., Contu, P., and Floris, C. Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results. The highest concentrations are in high energy demand areas such as your brain, heart and muscles. View abstract. Newer research illustrates the potential benefits of carnitines different forms, which may be used for various conditions, including heart and brain diseases (22, 23). Brevetti G, Diehm C, Lambert D, et al. L-Carnitine supplementation in older women. Eur Heart J 1989;10(6):502-508. View abstract. Nuesch R, Rossetto M, Martina B. Evaluation of the therapeutic efficacy and tolerability of levocarnitine propionyl in the treatment of chronic obstructive arteriopathies of the lower extremities: a multicentre controlled study vs. placebo. View abstract. Zhonghua Er.Ke.Za Zhi. Crill, C. M., Christensen, M. L., Storm, M. C., and Helms, R. A. J Pharm Sci 1995;84(5):627-633. . View abstract. Hum Reprod Update 1996;2:87-102. 2007;45(12):932-936. 2006;72(3):231-237. Clin Ter 3-31-1990;132(6 Suppl):479-510. A. View abstract. 2007;8(4):241-250. View abstract. Yang, L., Yin, H., Yang, R., and Huang, X. View abstract. Eidi, M., Pouyan, O., Shahmohammadi, P., Saeidi, H., Bahar, M., and Eidi, A. Interestingly, food sources of L-carnitine have a greater absorption rate than supplements. Eggs are so nutritious that they're often referred to as "nature's multivitamin." View abstract. Jpn Circ.J 1992;56(1):86-94. J Inherit.Metab Dis 2008;31 Suppl 2:S453-S456. Complement Ther Med 2011;19(4):216-227. View abstract. Dealberto, M. J. Valproate-induced hyperammonaemic encephalopathy: review of 14 cases in the psychiatric setting. 2011;42(3):217-225. Jing, L., Zhou, L. J., Li, W. M., Zhang, F. M., Yuan, L., Li, S., Song, J., and Sang, Y. Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. Circulation 5-1-1996;93(9):1685-1689. L-acetylcarnitine (L-AC) (Branigen) in the long term symptomatic treatment of senile dementia. Drugs Exper Clin Res 1983;9:925-934. Hemodial.Int. 2003;23(5):270-277. Rossini, M., Di, Munno O., Valentini, G., Bianchi, G., Biasi, G., Cacace, E., Malesci, D., La, Montagna G., Viapiana, O., and Adami, S. Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients. A., Bromberg, M. B., Chan, G. M., and Kissel, J. T. SMA CARNI-VAL trial part I: double-blind, randomized, placebo-controlled trial of L-carnitine and valproic acid in spinal muscular atrophy. View abstract. Hoffman, J. R., Ratamess, N. A., Gonzalez, A., Beller, N. A., Hoffman, M. W., Olson, M., Purpura, M., and Jager, R. The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students. View abstract. J Nutr 2007;137(3 Suppl 2):847S-849S. Metabolism Boosters: Weight Loss Fact or Fiction? [Ref], There have been reports from clinical trials of significant increases in platelet aggregation associated with high doses of levocarnitine (the active ingredient contained in L-Carnitine) (3 g/day) given to hemodialysis patients. 2005-2023 Healthline Media a Red Ventures Company. 2010;7:39. 2014 Feb;99(2):408-22. View abstract. 2011;93(4):799-808. Nutr Metab Cardiovasc Dis 2019;29(11):1151-67. doi: 10.1016/j.numecd.2019.07.012. View abstract. Conditioned nutritional requirements and the pathogenesis and treatment of myocardial failure. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Tarighat, Esfanjani A., Mahdavi, R., Ebrahimi, Mameghani M., Talebi, M., Nikniaz, Z., and Safaiyan, A. Res.Dev.Disabil. View abstract. 1 2020;42(6):386-390. Scand.J Clin Lab Invest 1985;45(2):169-178. Reduction of serum carnitine concentrations during anticonvulsant therapy with phenobarbital, valproic acid, phenytoin, and carbamazepine in children. Neurol.India 2008;56(3):391-393. Janiri, L., Martinotti, G., Tonioni, F., Ghelardini, C., Nicolai, R., Galeotti, N., Mosconi, L., Calvani, M., Bartolini, A., and Iannoni, E. Acetyl-L-carnitine in the management of pain during methadone withdrawal syndrome. Ciacci C, Peluso G, Iannoni E, et al. Kimmoun, A., Munagamage, G., Dessalles, N., Gerard, A., Feillet, F., and Levy, B. Effect of dialysate composition on the lipid response to L-carnitine supplementation. Spiekerkoetter, U., Bastin, J., Gillingham, M., Morris, A., Wijburg, F., and Wilcken, B. Z. Sarafoglou, K., Tridgell, A. H., Bentler, K., Redlinger-Grosse, K., Berry, S. A., and Schimmenti, L. A. Cardiac conduction improvement in two heterozygotes for primary carnitine deficiency on L-carnitine supplementation. 1990;5(3):263-265. I fell asleep at night but woke up repeatedly and then couldn't get back to sleep. View abstract. View abstract. Drugs 1999;58:479-87. Jacobs, P. L., Goldstein, E. R., Blackburn, W., Orem, I., and Hughes, J. J. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. View abstract. View abstract. randomized, multicenter open-label trials. View abstract. Int J Sports Med 1994;15(4):181-185. A., and Morrow, G. R. Pharmacologic treatment of cancer-related fatigue. View abstract. Benefits of L-carnitine. Cipolli, C. and Chiari, G. [Effects of L-acetylcarnitine on mental deterioration in the aged: initial results]. Neurobiol Aging 1995;16:1-4. Mingrone G. Carnitine in type 2 diabetes. View abstract. View abstract. Physiologie. View abstract. J Strength.Cond.Res. Brain Dev. View abstract. 2008;21(11):1231-1237. J Inherit.Metab Dis 6-15-2010; View abstract. Biogerontology. The effects of L-carnitine supplementation on lipid concentrations inpatients with type 2 diabetes: A systematic review and meta-analysis of randomized clinical trials. Thomsen, J. H., Shug, A. L., Yap, V. U., Patel, A. K., Karras, T. J., and DeFelice, S. L. Improved pacing tolerance of the ischemic human myocardium after administration of carnitine. Duranay, M., Akay, H., Yilmaz, F. M., Senes, M., Tekeli, N., and Yucel, D. Effects of L-carnitine infusions on inflammatory and nutritional markers in haemodialysis patients. J Anal Toxicol 1996;20:55-8. Tumori 2005;91(2):135-138. Loffredo, L., Pignatelli, P., Cangemi, R., Andreozzi, P., Panico, M. A., Meloni, V., and Violi, F. Imbalance between nitric oxide generation and oxidative stress in patients with peripheral arterial disease: effect of an antioxidant treatment. 1999; Mitwalli, A. H., Al-Wakeel, J. S., Alam, A., Tarif, N., Abu-Aisha, H., Rashed, M., and Al, Nahed N. L-carnitine supplementation in hemodialysis patients. View abstract. 2008;15(8):595-601. PLoS.One. View abstract. View abstract. Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. View abstract. Available for Android and iOS devices. 2011;17(6):I15-I23. View abstract. Brevetti G, Perna S, Sabba C, et al. View abstract. Long-term effect of acetyl-L-carnitine on myocardial 123I-MIBG uptake in patients with diabetes. Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R. Indications that topical L-carnitin-L-tartrate promotes human hair growth in vivo. 2011;31(5):376-377. 2010;58(5):551-565. By naturally getting rid of brain fog while assisting with problematic insomnia issues, N-Acetyl-L-Carnitine is the optimal inclusion in the ProMind Complex formula that will also enhance energy . J Inherit.Metab Dis 2008;31(4):503-507. View abstract. Gastrointestinal Int J Clin Pharmacol Res 1992;12:299-304. View abstract. Lagioia, R., Scrutinio, D., Mangini, S. G., Ricci, A., Mastropasqua, F., Valentini, G., Ramunni, G., Totaro, Fila G., and Rizzon, P. Propionil-L-carnitine: a new compound in the metabolic approach to the treatment of effort angina. L-Carnitine Supplement Side Effects. Oncologist 2010;15:200-11. Ishii, K., Komaki, H., Ohkuma, A., Nishino, I., Nonaka, I., and Sasaki, M. Central nervous system and muscle involvement in an adolescent patient with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency. 2003;79(2):292-300. Superiority of L-propionylcarnitine vs L-carnitine in improving walking capacity in patients with peripheral vascular disease: an acute, intravenous, double-blind, cross-over study. View abstract. View abstract. The effect of L-carnitine supplementation on plasma carnitine levels and various performance parameters of male marathon athletes. J.Altern.Complement Med. Amino.Acids 2009;36(2):365-372. [A systematic review of the effectiveness of alternative weight-loss products' ingredients]. By Steve Blechman BREAKING NEWS! Rizos I. 2009;10(2):103-110. Int.J Vitam.Nutr.Res. Here are 10 nootropic supplements proven to have brain-boosting benefits. J Inherit.Metab Dis 9-10-2010; View abstract. J Vasc.Surg. However, some individuals may experience digestive side effects when taking L-carnitine. View abstract. Ren Fail. A therapeutic alternative for hemodialysis patients. Seattle, WA: University of Washington, Seattle;1993. View abstract. Store at room temperature away from moisture and heat. Research shows that your levels tend to decline as you age (63, 64). Rev.Med.Chil. De Vecchi, A. F., Arduini, A., Di, Liberato L., and Bonomini, M. [L-carnitine in peritoneal dialysis]. Coulter DL. Int J Sports Med 1989;10(3):169-174. [Short-term medication of L-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia]. However, popular claims about supplements dont always match up with the science. Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication. 11-15-2008;102(10):1413-1417. Clin Rheumatol. View abstract. It appears to be safe used on a short-term basis. View abstract. Human studies indicate that taking acetyl-L-carnitine daily helps reverse the decline in brain function associated with Alzheimers and other brain diseases (32, 33, 34). Torrioli, M. G., Vernacotola, S., Mariotti, P., Bianchi, E., Calvani, M., De Gaetano, A., Chiurazzi, P., and Neri, G. Double-blind, placebo-controlled study of L-acetylcarnitine for the treatment of hyperactive behavior in fragile X syndrome. View abstract. 2008;8:365. View abstract. View abstract. View abstract. View abstract. Wang DD, Wang TY, Yang Y, He SM, Wang YM. Acta Toxicol Ther 1990;11(2):173-184. Malaguarnera, M., Bella, R., Vacante, M., Giordano, M., Malaguarnera, G., Gargante, M. P., Motta, M., Mistretta, A., Rampello, L., and Pennisi, G. Acetyl-L-carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy. Brevetti G, Perna S, Sabba C, et al. View abstract. El-Beshlawy, A., Youssry, I., El-Saidi, S., El, Accaoui R., Mansi, Y., Makhlouf, A., and Taher, A. L-carnitine may increase the risk of seizures in those with epilepsy. Curr Med Res Opin 1990;11:638-47. Zhonghua Nei Ke.Za Zhi. View abstract. 2011;22(6):1155-1159. View abstract. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. Res Pharm Sci. In an eight-week study in 38 women who exercised four times per week, there was no difference in weight loss between those who took L-carnitine and those who didnt (24). Ren Fail. Clin Nephrol. View abstract. Your L-carnitine levels are influenced by how much youre eating and how much your body is producing. Basic Clin Pharmacol Toxicol. About 98% of your L-carnitine stores are contained in your muscles, along with trace amounts in your liver and blood (17, 18). Rett syndrome: randomized controlled trial of L-carnitine. View abstract. View abstract. These side effects may go away during treatment as your body adjusts to the medicine. Huang, W. W., Wang, M. Y., Shi, H. M., Peng, Y., Peng, C. S., Zhang, M., Li, Y., Lu, J., and Li, X. Quality of life during and between hemodialysis treatments: role of L- carnitine supplementation. Ren Fail. Some research suggests that L-carnitine may help prevent or reduce symptoms of an overactive thyroid, such as insomnia, nervousness, heart palpitations, and tremors. For most individuals, the nausea and vomiting will be relatively mild. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. J Inherit.Metab Dis 2006;29(2-3):288-298. L carnitine side effects, safety, danger, caution, risks. Bohles H, Noppeney T, Akcetin Z, and et al. Hepatol. View abstract. Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. View abstract. 2010;16(1):5-14. De Pasquale, B., Righetti, G., and Menotti, A. Sabry, A. View abstract. View abstract. 2011;18(1):18-22. J Am Coll Nutr 1999;18:77-82. Mikhailova, T. L., Sishkova, E., Poniewierka, E., Zhidkov, K. P., Bakulin, I. G., Kupcinskas, L., Lesniakowski, K., Grinevich, V. B., Malecka-Panas, E., Ardizzone, S., D'Arienzo, A., Valpiani, D., Koch, M., Denapiene, G., Vago, G., Fociani, P., Zerbi, P., Ceracchi, M., Camerini, R., and Gasbarrini, G. Randomised clinical trial: the efficacy and safety of propionyl-L-carnitine therapy in patients with ulcerative colitis receiving stable oral treatment. Dal Negro R, Pomari G, Zoccatelli O, and et al. View abstract. van Dalen, E. C., Caron, H. N., Dickinson, H. O., and Kremer, L. C. Cardioprotective interventions for cancer patients receiving anthracyclines. Korean J Gastroenterol. 2007;25(2):182-188. View abstract. Muniyappa, R. Oral carnitine therapy and insulin resistance. Circ Rep 2019;1(11):508-516. Int.J Cosmet.Sci 2011;33(6):519-526. Eur.J Clin.Nutr. Med Sci Sports Exerc. Kuwasawa-Iwasaki M, Io H, Muto M, et al. Postgrad Med J 1996;72:45-50. View abstract. J Int.Soc.Sports Nutr. View abstract. Fertil.Steril 2003;80(Suppl 3):48. View abstract. 2009;16(1):53-56. View abstract. View abstract. View abstract. Schoderbeck M, Auer B, Legenstein E, et al. A bidimensional echocardiographic study]. View abstract. Indian Pediatr 1992;29:1501-5. View abstract. View abstract. J Trop.Pediatr. According to the University of Maryland Medical Center, carnitine is successful in treating hyperthyroidism possibly because of its ability to block the effects of thyroid hormones - a potentially dangerous effect for people suffering from an underactive thyroid. View abstract. Clin Endocrinol (Oxf) 2016;84(6):851-7. However, there were some mild side effects, including nausea and stomach discomfort (24, 58). Ann.Saudi.Med. View abstract. Drugs Exp Clin Res 1987;13:417-23. If you've had a seizure before, you should not take carnitine. Perrott, J., Murphy, N. G., and Zed, P. J. L-carnitine for acute valproic acid overdose: a systematic review of published cases. Am Heart J 2000;139:S120-3. Loumbakis P, Anezinis P, Evangeliou A, and et al. Rausch CR, Paul S, Marx KR, et al. View abstract. Zhang, X. L. and Ge, H. Clinical observations on treating ischemic cardiomyopathy using Fasudil and L-carnitine. This may lead to irritability, hyperactivity or insomnia. 2012;1:CD008427. Zhao, J. L., Gao, D. Z., Liu, D., He, H. H., She, Q., and Yin, Y. H. Improvement of exercise tolerance by L-carnitine in patients with cardiac syndrome X. Chin.Hosp.Pharm.J. Common L-carnitine side effects include stomach pain, nausea, vomiting and diarrhea. Saneian H, Khalilian L, Heidari-Beni M, et al. View abstract. View abstract. Soczynska, J. K., Kennedy, S. H., Chow, C. S., Woldeyohannes, H. O., Konarski, J. Greig, C., Finch, K. M., Jones, D. A., Cooper, M., Sargeant, A. J., and Forte, C. A. Insomnia; Energy drinks can cause insomnia, especially when it . View abstract. Does carnitine cause high blood pressure? Am.J Clin Nutr. 2009;10(12):1875-1882. View abstract. Cavallini, G., Ferraretti, A. P., Gianaroli, L., Biagiotti, G., and Vitali, G. Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia. Alcohol Alcohol 2010;45(5):449-455. Pharmacol Rev 2002;54:589-98. Abbasnezhad A, Choghakhori R, Kashkooli S, Alipour M, Asbaghi O, Mohammadi R. Effect of L-carnitine on liver enzymes and biochemical factors in hepatic encephalopathy: A systematic review and meta-analysis. Examples: atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal), sotalol (Betapace), timolol (Timoptic) and some other drugs whose chemical names end with "-olol." How they can cause insomnia: Beta-blockers have long been associated with sleep disturbances, including awakenings at night and nightmares. View abstract. It is used for weight loss and may have an impact on brain function. The early effects of intravenous L-propionyl carnitine on ulcerative trophic lesions of the lower limbs in arteriopathic patients: a controlled randomized study. Zhang, J. M., Gu, X. F., Shao, X. H., Song, X. Q., Han, L. S., Ye, J., Qiu, W. J., Gao, X. L., Wang, Y., and Wang, M. X. De Ritis G, Picardo S, Brancadoro D, and et al. 2010;37(12):2353-2354. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. Xue, Y. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. View abstract. Some side effects may not be reported. Clin Physiol 1984;4(4):363-365. L-arginine should be used with caution. Aliment.Pharmacol Ther 2011;34(9):1088-1097. Trovato GM, Ginardi V, Di Marco V, and et al. Carnitine in the therapy of dyslipidemic patients. Vivekanandan, S. and Nayak, S. D. Valproate-induced hyperammonemic encephalopathy enhanced by topiramate and phenobarbitone: a case report and an update. L-Carnitine in the treatment of fatigue in adult celiac disease patients: a pilot study. Khajeh B, Dashti-Khavidaki S, Nasiri-Toosi M, Mohammadi K, Jafari A. Zidovudine-induced mitochondrial myopathy is associated with muscle carnitine deficiency and lipid storage. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to levocarnitine: injectable solution, oral capsule, oral solution, oral tablet. Riccioni, C., Sarcinella, R., Palermo, G., Izzo, A., Liguori, M., Koverech, A., Messano, M., and Virmani, A. View abstract. Immunopharmacol.Immunotoxicol. View abstract. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. B., Burlina, A. P., Dixon, M., Duran, M., Goodman, S. I., Koeller, D. M., Muller, E., Naughten, E. R., Neumaier-Probst, E., Okun, J. G., Kyllerman, M., Surtees, R. A., Wilcken, B., Hoffmann, G. F., and Burgard, P. Guideline for the diagnosis and management of glutaryl-CoA dehydrogenase deficiency (glutaric aciduria type I). Optom.Vis.Sci 2011;88(12):1439-1444. Cell Death.Dis 2010;1:e62. Spiering, B. View abstract. L-carnitine can absolutely cause heart disease - but only if you have the gut microbes needed to break it down, he said. The effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation in migraine prophylaxis. 2007;52(6):1774-1775. 2010;610:285-308. Rahbar, A. R., Shakerhosseini, R., Saadat, N., Taleban, F., Pordal, A., and Gollestan, B. Cifone MG, Alesse E, Di Marzio L, et al. Call your doctor at once if you have: Common side effects of L-Carnitine may include: This is not a complete list of side effects and others may occur. LevOCARNitine (levOCARNitine)." Clinical evaluation of the effects of levocarnitine chloride (LC-80) on excercise tolerance in stable angina pectoris by the serial multistage treadmill exercise testing: a multicenter, double-blind study.